|
Ultram is non-opiod analgesic used in the treatment and prevention
of pain.
Ultram (Tramadol hydrochloride) is a white, bitter, crystalline
and odorless powder. Each Ultram tablet tablet tablet contains 50
mg of tramadol hydrochloride and is white in color. Ultram is supplied
as a 50 mg (white, film-coated capsule-shaped tablet) which is engraved
with "McNeil" on one side and on one side and "659"
on the other side.
| DRUG |
DOSAGE |
QUANTITY |
CONSULT |
PRICES |
|
 |
|
|
Ultram |
50mg |
30 tabs |
FREE |
140 |
Order |
| Ultram |
50mg |
90 tabs |
FREE |
294 |
Order |
|
 HOW
DOES ULTRAM WORK?
ULTRAM acts on the central nervous system and unlike codeine
and its derivative medications is a totally synthetic analgesic
compound. Although its mode of action is not completely understood,
from animal tests, at least two complementary mechanisms appear
applicable: the binding of parent compound and its metabolite to
opioid receptors and weak inhibition of reuptake of norepinephrine
and serotonin by nerves located within the central nervous system.
ULTRAM-induced analgesia is only partially reversed by the opiate
antagonist naloxone in several animal tests. ULTRAM has been shown
to inhibit reuptake of norepinephrine and serotonin in vitro. These
mechanisms may contribute independently to the overall analgesic
profile of ULTRAM. Analgesia in humans begins approximately within
one hour after administration and reaches a peak in approximately
two to three hours.
Top
HOW EFFECTIVE IS ULTRAM?
ULTRAM has been given in single oral doses of 50, 75, 100, 150 and
200 mg to patients with pain following surgical procedures and pain
following oral surgery (extraction of impacted molars). In single-dose
models of pain following oral surgery, pain relief was demonstrated
in some patients at doses of 50 mg and 75 mg. A dose of 100 mg of
ULTRAM tended to provide analgesia superior to codeine sulfate 60
mg, but it was not effective as the combination of aspirin 650 mg
with codeine phosphate 60 mg. In single-dose models of pain following
surgical procedures, 150 mg provided analgesia generally comparable
to the combination of acetaminophen 650 mg with propoxyphene napsylate
100 mg, with a tendency toward later peak effect. ULTRAM has been
studied in three long-term controlled trials involving a total of
820 patients, with 530 patients receiving ULTRAM. Patients with
a variety of chronic painful conditions were studied in double-blind
trials of one to three months duration. Average daily doses of approximately
250 mg of ULTRAM in divided doses were generally comparable with
five doses of acetaminophen 300 mg with codeine phosphate 30 mg
(Tylenol with Codeine #3) daily, five doses of aspirin 325 mg with
codeine phosphate 30 mg daily, or two to three doses of acetaminophen
500 mg with oxycodone hydrochloride 5 mg (Tylox) daily.
Top
HOW DO I USE ULTRAM?
For the treatment of painful conditions ULTRAM 50 mg to 100 mg can
be administered as needed for relief every four to six hours, not
to exceed 400 mg per day. For moderate pain ULTRAM 50 mg may be
adequate as the initial dose, and for more severe pain, ULTRAM 100
mg is usually more effective as the initial dose.
Individualization of Dose:
Patients 65 to 75 years of age: No dose adjustment is necessary.
Patients over 75 years old: No more then 300 mg/day in divided doses.
Patients with kidney impairment: The dosing interval of ULTRAM should
be increased to 12 hours with a maximum daily dose of 200 mg.
Dialysis patients: These patients can receive their regular dose
on the day of dialysis.
Patients with cirrhosis: Recommended dosage is 50 mg every 12 hours.
Patients receiving chronic carbamazepine: Doses up to 800 mg daily
may be required, this is up to twice the recommended dose of ULTRAM.
Top
DRUG ABUSE AND DEPENDENCE:
ULTRAM has a potential to cause psychic and physical dependence
of the morphone-type. The drug has been associated with craving,
drug-seeking behavior and tolerance development. Cases of abuse
and dependence on ULTRAM have been reported.
ULTRAM should not be used in opioid-dependent patients. ULTRAM can
reinitiate physical dependence in patients that have been previously
dependent or chronically using other opioids. In patients with a
tendency to drug abuse, a history of drug dependence, or are chronically
using opioids, treatment with ULTRAM is not recommended.
ULTRAM AND SEIZURES:
Seizure Risk: Seizures have been reported in patients receiving
ULTRAM within the recommended dosage range. Concomitant use of ULTRAM
increases the seizure risk in patients taking:
Selective serotonin reuptake inhibitors (SSRI antidepressants or
anoretics -phentermine),
Tricyclic antidepressants and other tricyclic compounds (e.g., cyclobenzaprine,
promethazine, etc.),
Opioids,
MAO inhibitors,
Neuroleptics,
Any drugs that reduce the seizure threshold,
Epilepsy.
Top
ULTRAM AND DROWZINESS:
ULTRAM may impair mental or physical abilities required for the
performance of potentially hazardous tasks such as driving a car
or operating machinery.
ULTRAM should not be taken with alcohol containing beverages.
ULTRAM should be used with caution when taking medications such
as tranquilizers, hypnotics or other opiate containing analgesics.
ULTRAM AND PREGNANCY:
ULTRAM should not be used in pregnant women or nursing mothers,
safe use in pregnancy has not been established.
Chronic use during pregnancy may lead to physical dependence and
post-pregnancy withdrawal symptoms in the newborn.
ULTRAM has been shown to cross the placenta. Nonetheless, the effect
of ULTRAM, if any, on the later growth, development, and functional
maturation of the child is unknown.
Top
OVERDOSAGE:
Serious potential consequences of over dosage are respiratory depression
and seizure.
ADDITIONAL QUESTIONS:
Not every question can be addressed in this FAQ
page. If any additional questions remain we suggest you contact
your local physician or email us at patientcare@phentermine-direct.net.
At Phentermine-Direct.net, we do all that we can to insure your
safety.
|
